Ralph A. Chappa,Michael J. Burkstrand,David E. Babcock,CHAPPA, Ralph, A.,BURKSTRAND, Michael, J.,BABCOCK, David, E.
申请号：
US13281802
公开号：
US20120100187A1
申请日:
2011.10.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Embodiments of the invention include multi-layer coatings and methods for controlling the elution of hydrophilic active agents. In an embodiment, the invention includes a medical device including a substrate, a primer polymer layer disposed on the substrate, an expandable layer disposed on the primer polymer layer, and a hydrophilic active agent dispersed within the expandable layer. In an embodiment, the invention includes a method of forming a medical device including depositing a primer layer onto a substrate, the primer layer comprising a primer polymer. The method can further include depositing an expandable layer onto the primer layer, the expandable layer including an expandable polymer, and a hydrophilic active agent. The expandable layer can be deposited with a solvent that is effective to solvate both the expandable polymer and the primer polymer. Other embodiments are also included herein.
