PENDRI, Annapurna,LANGLEY, David R.,GERRITZ, Samuel,LI, Guo,ZHAI, Weixu,D'ANDREA, Stanley,PATEL, Manoj,NAIDU, B. Narasimhulu,PEESE, Kevin,WANG, Zhongyu
申请号：
ES13710240
公开号：
ES2606486T3
申请日:
2013.03.04
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I ** Formula ** in which: X is C or N； R1 is hydrogen or Ar1； R2 is hydrogen or Ar1； with the proviso that when X is C R1 it is Ar1 and R2 is hydrogen or R2 is Ar1 and R1 is hydrogen, and when X is N R1 it is Ar1 and R2 is hydrogen； R3 is N (R6) (R7)； R4 is C1-C6 alkyl or haloalkyl； R5 is C1-C6 alkyl； R6 is hydrogen or C1-C6 alkyl； R7 is hydrogen or C1-C6 alkyl； or N (R6) (R7) taken together is azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl, or homomorpholinyl, and is substituted with 0-3 substituents selected from halo, C1-C6 alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, carboxy, or carboxamido； or N (R6) (R7) taken together is indolinyl, isoindolinyl, tetrahydroisoquinolinyl, or decahydroisoquinolinyl, and is substituted with 0-3 substituents selected from halo, C1-C6 alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, carboxy, or carboxamido ； or N (R6) (R7) taken together is an amine [4.2.0.], [4.3.0.], [4.4.0.], [4.5.0.], [4.6.0.], [ 5.2.0.], [5.3.0.], [5.4.0.], [5.5.0.], [5.6.0.], [6.2.0.], [6.3.0.], [6.4 .0.], [6.5.0.], [6.6.0.] Spirocyclic； or N (R6) (R7) taken together is ** Formula ** and Ar1 is phenyl, pyridinyl, or biphenyl and is substituted with 0-3 substituents selected from halo, C1-C6 alkyl, haloalkyl, C3-C7 cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, phenyl, benzyl, phenoxy, and benzyloxy wherein said phenyl, benzyl, phenoxy, and benzyloxy is substituted with 0-3 halo substituents, C1-C6 alkyl, haloalkyl, C3-C7 cycloalkyl, halocycloalkyl, alkoxy and haloalkoxy； or Ar1 is tetralinyl, ((methyl) indazolyl) phenyl, or (benzyloxy) phenyl； or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula I**Fórmula** en la que: X es C o N； R1 es hidrógeno o Ar1； R2 es hidrógeno o Ar1； con la condición de que cuando X es C R1 sea Ar1 y R2 sea hidrógeno o R2 sea Ar1 y R1 sea hidrógeno, y cuando X es N R1 sea Ar1 y R2 sea hidrógeno； R3 es N(R6)(R7)； R4 es alquilo o haloalquilo C1-C
