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חומרים מדכאי 2–masp לשימוש בטיפול ב– המוגלובינוריה התקפית לילית (pnh)
专利权人:
UNIVERSITY OF LEICESTER;OMEROS CORPORATION
发明人:
申请号:
IL22875813
公开号:
IL228758A
申请日:
2013.10.06
申请国别(地区):
IL
年份:
2019
代理人:
摘要:
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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