The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies have utility in the treatment of subjects with a coagulopathy.本發明係關於一種可特異性結合組織因子路徑抑制子(TFPI)且減少血液之凝結時間之抗體。此等抗體可用於治療患有凝血障礙之個體。