Universidad Catolica De Cordoba;Consejo Nacional De Investigaciones Cientificas Y Tecnicas (CONICET)
发明人:
Lujan, Hugo Daniel
申请号：
AU2009323734
公开号：
AU2009323734B2
申请日:
2009.12.02
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.
