The present invention relates to a composition for preventing or treating hyperpigmentation, and in the present invention, as a result of screening a substance that inhibits melanin production, the compounds (L-765,314) of the present invention inhibit the PKC (protein kinase C) signaling pathway. As a result, it was confirmed that the tyrosinase activity was inhibited and melanin production was reduced.The compound of the present invention having the above effect is for the prevention or treatment of hyperpigmentation diseases, or a pharmaceutical composition for whitening, preventing or improving hyperpigmentation diseases It can be usefully used as a cosmetic composition for, or a cosmetic composition for whitening, a health food composition for preventing or improving hyperpigmentation diseases, or a health food composition for whitening.본 발명은 과색소침착 예방 또는 치료용 조성물에 관한 것으로, 본 발명에서는 멜라닌 생성을 억제하는 물질을 스크리닝한 결과, 본 발명의 화합물(L-765,314)이 PKC(protein kinase C) 신호전달 경로를 억제하여 티로시나아제 활성을 억제하고 멜라닌 생성을 감소시키는 것을 확인한 바, 상기와 같은 효과를 가지는 본 발명의 화합물은 과색소침착질환 예방 또는 치료용, 또는 미백용 약학 조성물, 과색소침착질환 예방 또는 개선용 화장료 조성물, 또는 미백용 화장료 조성물, 과색소침착질환 예방 또는 개선용 건강식품 조성물, 또는 미백용 건강식품 조성물 등으로 유용하게 활용될 수 있다.
