Dihydroindolone derivatives (I) and their optical and geometric isomers, or addition salts with an acid or base are new. Dihydroindolone derivatives of formula (I) and their optical and geometric isomers, or addition salts with an acid or base are new. m : 1 or 2 n : 1 or 2 A : a pyrrolyl group optionally substituted by 1-3 groups of 1-6C alkyl X : C(O), S(O) or SO 2 either R 1>, R 2> : 1-6C alkyl or NR 1>R 2> : a heterocyclic group R 3>R 4> : a heterocyclic group R 5> : H or 1-6C alkyl and R 6> : H or halo, where the heterocyclic group is a mono or bicyclic 5-8 membered group (optionally containing one to three heteroatoms of N, O or S, and one or more unsaturations, and optionally substituted by one or more 1-6C alkyl, 1-6C alkenyl, oxo, hydroxy, 1-6C alkoxy, aryl, arylalkyl or arylalkenyl), the aryl is phenyl group optionally substituted by one or more halo or 1-6C alkyl, and X represents the double bond, which is in configuration is Z or E. Independent claims are included for: (1) the preparations of (I) and (2) combination comprising (I) with an anticancer agent comprising genotoxic agents, mitotic poisons, antimetabolites, proteasome inhibitors or kinase inhibitors. [Image] - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : None given.Composés de formule (I) :dans laquelle :▪ m et n représentent 1 ou 2,▪ A représente un groupement pyrrolyle,▪ X représente le groupement C(O), S(O) ou SO2▪ R1 et R2 représentent un groupement alkyle,ou forment ensemble avec latome dazote qui les porte un groupement hétérocyclique,▪ R3 et R4 forment ensemble avec les atomes qui les portent un groupement hétérocyclique,▪ R5 représente un atome dhydrogène ou un groupement alkyle,▪ R6 représente un atome dhydrogène ou un atome dhalogène,
