ELLMARK Peter Bo Joakim,ELLMARK Peter Bo Joakim,DAHLEN Eva Maria,DAHLEN Eva Maria
申请号：
SI201231140
公开号：
SI2753646T1
申请日:
2012.09.05
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell activation which is higher than, or is equal to, the potency for B cell activation and wherein the antibody, antigen-binding fragment, or fusion, variant or derivative thereof has an affinity (KD) for CD40 of less than 1×10−10 M, which have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.
