Systems and methods for enhancing the selective targeting of agents (204) forpreferential action at a target with reduced action with healthy tissue distalthe target tissue. One or more agents (204) can be combined with nano scale structures/particles(202) for delivery to the target tissue. Appropriate bombardment with acceleratedparticle radiation, such as proton radiation, induces the release of the agents(204) at the target site. Nano carriers can be combined with therapeutic and/orimaging enhancement agents (204). Imaging of the target tissue can provide averification of the delivered dose of particle radiation. Nanocarriers canbe provided with an outer shell selected for biocompatibility and durabilityin the in vivo environment and further selected to provide a feedback mechanismin the treatment environment to accelerate the release of the agent (204) andreduce a total radiation dose needed for that release.
