A canine wound boot is fabricated using a breathable substrate having two layers of generally open weave and a fibrous material spacing and bonding the two layers together. Onto the substrate, various friction pads, wear pads, one or more straps, and strategically located cushions are attached. Specially configured slits ensure that a wide range of leg sizes relative to paw sizes may be accommodated, while easing application of the boot and eliminating any risk of bunching. Elastic material serves as a gusset in the boot which expands to cover a bandage or cast.