Brian Lannutti,Todd Covey,Allard Kaptein,Dave Johnson,Jay Stamatis,Cecile M. Krejsa,John Gregory Slatter
申请号：
US16355227
公开号：
US20190314369A1
申请日:
2019.03.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
In an embodiment, therapeutic methods and uses of Bruton's Tyrosine Kinase (BTK) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for a BTK inhibitor for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described.
