The invention relates to Intra Vaginal Ring (IVR) which contains dehydrated rehydrated vesicles (DRV) dispersion comprising dual active ingredients, one is from Selective Estrogen Receptor Modulator (SERM) and another is from Gonadotropin Releasing Hormone Analogue (GnRH). The present invention also relates to the site specific release at uterus through vaginal route. The present invention also relates to the IVR comprising dehydrated rehydrated vesicles (DRV) dispersion which makes it possible to achieve sustained release, increase patient compliance as well bioavailability of active ingredients.
