THOMAS LAWRENCE J,KELER TIBOR,MARSH HENRY C,VITALE LAURA A,HE LIZHEN
申请号：
NZ62380711
公开号：
NZ623807A
申请日:
2011.04.13
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is an isolated monoclonal antibody which binds to human CD27, wherein the antibody comprises: (i) a heavy chain variable region CDR1 comprising GFTFSSYW, a heavy chain variable region CDR2 comprising IKQDGSEK, a heavy chain variable region CDR3 comprising VRELGMDWYFDL, a light chain variable region CDR1 comprising QSVDSY or QSVSSY, a light chain variable region CDR2 comprising DAS, and a light chain variable region CDR3 comprising QQRSNWPPT (ii) a heavy chain variable region CDR1 comprising GFTFSSYD, a heavy chain variable region CDR2 comprising IWNDGSNK, a heavy chain variable region CDR3 comprising VGGTADLEHWDQ, a light chain variable region CDR1 comprising QGISSW, a light chain variable region CDR2 comprising AAS and a light chain variable region CDR3 comprising QQYNSYPLT (iii) a heavy chain variable region CDR1 comprising GFTFNIYD a heavy chain variable region CDR2 comprising IWYDGSNQ, a heavy chain variable region CDR3 comprising ARGTHWGYFDY, a light chain variable region CDR1 comprising QGISSW, a light chain variable region CDR2 comprising AAS, and a light chain variable region CDR3 comprising QQYNSYPRT (iv) a heavy chain variable region CDR1 comprising GFSFSSYG, a heavy chain variable region CDR2 comprising LWYDGSHK, a heavy chain variable region CDR3 comprising AREGLAVPGHWYFDL, a light chain variable region CDR1 comprising QGISSA, a light chain variable region CDR2 comprising DAS, and a light chain variable region CDR3 comprising QQFNTYPRT (v) a heavy chain variable region CDR1 comprising GFTLSSHD, a heavy chain variable region CDR2 comprising IWNDGSNK, a heavy chain variable region CDR3 comprising VRGTADLEHWDQ, a light chain variable region CDR1 comprising QGISSW, a light chain variable region CDR2 comprising AAS, and a light chain variable region CDR3 comprising QQYNSYPLT (vi) a heavy chain variable region CDR1 comprising GFTFSHYG, a heavy chain variable region CDR2 comprising IWYDGSNK, a heavy chain variable region CDR3 comprising ARDGWTTMVRGLNV
