UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.;Food and Drug Administration
发明人:
Biao He,Steven A. Rubin
申请号：
US16352135
公开号：
US20190216918A1
申请日:
2019.03.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention provides the complete genomic sequence of the epidemic mumps virus (MuV) strain MuVIowa/US/06. Further, a reverse genetics system was constructed and used to rescue recombinant viral constructs that are attenuated compared to rMuVIowa/US/06 and JL vaccine viruses. Such constructs include viral constructs lacking the open reading frame (ORF) of the SH gene (rMuVΔ；SH) and/or incapable of expressing the V protein (rMuVΔ；V).
