The present invention provides a pharmaceutical composition and food composition with strains of lactic acid bacteria for improving of kidney disease and inhibiting inflammation, which comprises an isolated lactic acid bacteria strain. The isolated lactic acid bacteria strain selected from at least one of following group or the combination thereof: BLI-02 (Bifidobacterium longumsubsp. infantis), TYCA06 (Lactobacillus acidophilus) and VDD088 (Bifidobacterium bifidum).本發明提供一種用於改善腎病及抑制發炎之包含乳酸菌菌株的醫藥組合物及食品組合物,其包含經分離的乳酸菌菌株,該乳酸菌菌株選自以下群組中之至少其中之一或組合:長雙歧桿菌嬰兒亞種(Bifidobacterium longum subsp.infantis) BLI-02菌株,寄存編號BCRC 910812、嗜酸乳酸桿菌(Lactobacillus acidophilus) TYCA06菌株,寄存編號BCRC 910813、以及兩歧雙歧桿菌(Bifidobacterium bifidum) VDD088菌株,寄存編號BCRC 910814。