A new and distinct cultivar of Hosta named ‘First Blush’, characterized by its medium sized mounding clump, green leaves with purplish-red colored petioles on both sides, that emerge with a thin purplish-red margin, become (“blush”) purplish-red on the upward side of the leaf blade in the space between the veins, and producing purple flowers on purplish-red scapes. In combination these traits set ‘First Blush’ apart from all other existing varieties of Hosta known to the inventor.