Mendez, Michael,Klapholz, Sue,Kucherlapati, Raju,Jakobovits, Aya,Green, Larry
申请号：
AU2008200005
公开号：
AU2008200005B2
申请日:
2008.01.02
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2008200005B220120517.pdf#####ABSTRACT The present invention relates to transgenic 5 non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and VK) gene regions. Advantageously, the inclusion of plural variable region 10 genes enhances the specificity and diversity of human antibodies produced by - the animal. Further, the inclusion of such regions enhances and reconstitutes Bcell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high 15 affinity anitbodies. 20 25 30 35
