An antimicrobial coating system and method are described. In some embodiments,a system may include a composition. The composition may include one or more bridgedpolycyclic compounds. At least one of the bridged polycyclic compounds may includeat least two cyclic groups, and at least two of the cyclic groups may include quaternaryammonium moieties. In some embodiments, a method may include applying an antimicrobialcoating to an oral surface, a surface of a construction substrate, a surface ofa marine substrate, a surface of a medical device, or a surface of a personal caredevice. The protective coating may be antimicrobial. A protective coating mayinclude antimicrobial bridged polycyclic compounds. Bridged polycyclic compoundsmay include quaternary ammonium compounds. Bridged polycyclic compounds basedcoating systems may impart self-cleaning properties to a surface (e.g., a toothsurface).