The present invention relates to a nucleic acid complex having a new structure capable of introducing a biologically active nucleic acid into a cell, a therapeutic and diagnostic composition containing the same, and a method for regulating expression of a target gene using the same, more specifically, A nucleic acid complex in which a physiologically active nucleic acid and a carrier peptide nucleic acid (Carrier Peptide Nucleic Acid) modified to have a positive charge as a whole are complementarily bound, and a composition for treatment and diagnosis of a disease comprising the same, The present invention also relates to a method for regulating expression of a target gene using the same.本発明は、生理活性核酸を細胞内に導入できる新しい構造の核酸複合体、それを含む疾病の治療および診断用組成物、並びにそれを用いた標的遺伝子の発現調節方法に関し、より詳細には、生理活性核酸と、全体的に陽電荷を有するように改変されたキャリアペプチド核酸（Ｃａｒｒｉｅｒ Ｐｅｐｔｉｄｅ Ｎｕｃｌｅｉｃ Ａｃｉｄ）とが相補的に結合された核酸複合体、それを含む疾病の治療および診断用組成物、並びにそれを用いた標的遺伝子の発現調節方法に関する。
