IYER, Raman Mahadevan,LAINE, Dramane Ibrahim,LOPEZ-TAPIA, Francisco Javier,PHILLIPS, Jonathan E,STEVENSON, Christopher
申请号：
HK16103822.0
公开号：
HK1215855A
申请日:
2016.04.05
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
This application discloses the Btk inhibitor compounds 6-tert-Butyl-8-fluoro-2-{3-hydroxymethyl-4-[1-methyl-5-(1&prime；-methyl-1&prime；,2&prime；,3&prime；,4&prime；,5&prime；,6&prime；-hexahydro-[3,4&prime；]bipyridinyl-6-ylamino)-6-oxo-1,6-dihydro-pyridazin-3-yl]-pyridin-2-yl}-2H-phthalazin-1-one, 2-(2-{3-[5-(5-Azetidin-1-ylmethyl-1-methyl-1H-pyrazol-3-ylamino)-1-methyl-6-oxo-1,6-dihydro-pyridazin-3-yl]-2-hydroxy methyl-phenyl}-8-fluoro-1-oxo-1,2-dihydro-isoquinolin-6-yl)-2-methyl-propionitrile, and 6-tert-Butyl-2-[2-hydroxymethyl-3-(5-{5-[(2-methoxy-ethylamino)-methyl]-pyridin-2-ylamino}-6-oxo-1,6-dihydro-pyridin-3-yl)-phenyl]-3,4-dihydro-2H-isoquinolin-1-one, formulations thereof, and methods of treatment of asthma, as described herein.
