A mobile agricultural sprayer includes a chemical tank that holds a chemical fluid to be sprayed at a worksite and a rinse fluid tank that holds rinse fluid. The mobile agricultural sprayer also includes a first sensor coupled to the rinse fluid tank configured to detect a characteristic of the rinse fluid within the rinse fluid tank, and, generate a first sensor signal indicative of the characteristic of the rinse fluid. The sprayer also includes a distribution system, including a fluidic pathway and a nozzle, configured to pump the rinse fluid from the rinse fluid tank along the fluidic pathway through the nozzle of the sprayer. The sprayer also includes a second sensor coupled to the fluidic pathway configured to detect a characteristic of the fluid within the fluidic pathway, and generate a second sensor signal indicative of the characteristic. The sprayer also includes a residue detection system configured to receive the first and second sensor signals and, based on the received sensor signals, determine a concentration of residue within the fluidic pathway.