Elfrida R. Benjamin;John W. F. Whitehead;Zhengming Chen;Laykea Tafesse;Samuel F. Victory;Deyou Sha
发明人:
Elfrida R. Benjamin,Zhengming Chen,Deyou Sha,Laykea Tafesse,Samuel F. Victory,John W. F. Whitehead
申请号：
US11665345
公开号：
US09000174B2
申请日:
2005.10.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to piperidinyl compounds of Formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to an assay useful for identifying such compounds as N-type calcium channel modulators or blockers. The invention is also directed to the compounds of Formula (I) and compounds identified by the above assay, and the use of such compounds to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
