Andrea Guido Oreste Manetti,Luigi Fiaschi,Marco Becherelli,Prachi Prachi,Massimiliano Biagini
申请号：
US14437862
公开号：
US20150273041A1
申请日:
2013.10.29
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The S. aureus Ser-Asp rich fibrinogen/bone sialoprotein-binding protein contains three CnaB domains, and that the third of these provides significant protection against S. aureus infection. Thus a useful S. aureus vaccine can include a SdrE CnaB domain. Furthermore, the SdrE protein has been shown to be relatively resistant to trypsin digestion, which could be connected to the observation that SdrE contains an isopeptide bond within the third CnaB domain.
