Problem: to develop an organ of a mammal having a complex cell structure consisting of a plurality of cells such as kidney, pancreas, thymus and hair in a non human animal.A method for producing said target organ from an individual host host mammal of an individual different from that of a human host mammal in the living body of a non human host mammal having an abnormality in which the generation of a target organ does not occur in the developmental stage A method for preparing a cell derived from a heterologous host mammal b) transplanting the cells into a blastocyst during the blastocyst stage of the non human host mammalian c) producing the fertilized egg in the fetal embryo of the non human host mammalian and ChildbirthProblem to be solved: to provide a method of manufacturing a target organ, including a step of obtaining the target organ from an individual.No selection【課題】腎臓、すい臓、胸腺及び毛などの複数種の細胞からなる複雑な細胞構成を有する哺乳動物の臓器を、非ヒト動物の生体中で作成すること。【解決手段】発生段階において目的臓器の発生が生じない異常を有する非ヒト宿主哺乳動物の生体内において、該ヒト宿主哺乳動物とは異なる個体の異個体宿主哺乳動物由来の該目的臓器を製造する方法であって、a)該異個体宿主哺乳動物由来の細胞を調製する工程;b)該非ヒト宿主哺乳動物の胚盤胞期の受精卵中に、該細胞を移植する工程;c)該受精卵を該非ヒト宿主哺乳動物の母胎中で発生させて、産仔を得る工程;およびd)該産仔個体から、該目的臓器を取得する工程;を含む、目的臓器を製造する方法を提供する。【選択図】なし
