The present invention is related to a nucleic acid molecule capable of binding to SDF 1 preferably capable of inhibiting SDF 1 whereby the nucleic acid molecule is for use in a method for the treatment and/or prevention of a disease or disorder for use in a method for the treatment of a subject suffering from a disease or disorder or being at risk of developing a disease or disorder as an adjunct therapy or for use as a medicament for the treatment and/or prevention of a disease or disorder whereby the disease or disorder is cancer.