UTILISATION D'OLIGONUCLEOTIDES DANS DES ETATS INFLAMMATOIRES REFRACTAIREES AUX STEROIDES OU DEPENDANTES DES STEROIDES

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专利权人:

INDEX PHARMACEUTICALS AB

发明人:

LOFBERG, ROBERT,VON STEIN, OLIVER,ZARGARI, AREZOU

申请号：

CA2612162

公开号：

CA2612162C

申请日:

2006.06.29

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention makes it possible to enhance steroid efficacy in asteroid refractory or dependent patient afflicted with an inflammatorycondition not responding or responding poorly or inadequately to anti-inflammatory treatment, by administering an oligonucleotide having thesequence 5 5'-Xm-CG-Yn-3' in an effective amount to said patient and wherein Xis A, T, C or G, Y is A, T, C, or G, m=1-100, n=1-100 and wherein at least oneCG dinucleotide is ummethylated. The invention also encompasses the use ofsaid oligonucleotide for the manufacture of pharmaceuticals.

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中国工程科技知识中心

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http://www.ckcest.cn/home/