MURPHY, EVELYN,CONNEELY, ORLA, M.,FITZGERALD, OLIVER,BRESIHAN, BARRY
申请号：
WO2001US15311
公开号：
WO0187923(A1)
申请日:
2001.05.11
申请国别(地区):
世界知识产权组织国际局
年份:
2001
代理人:
摘要：
Synovial CRH functions in a paracrine manner to induce the nuclear transcription factor NURR1, which is abundantly expressed in the inflammatory cells of both rheumatoid arthritis and psoriatic arthritis synovium. This induction is suppressed by glucocorticoids. The invention is directed to the pivotal role the NURR subfamily of transcription factors play in modulation of peripheral CRH and CRH-mediated signaling through the CRH-receptor subtype R1 alpha , particularly in the inflammatory process in human arthritis.
