Female contraceptive compositions (A) comprise nomegestrol (or its ester) as progestational component (I) and estradiol (or its ester) as estrogenic component (II), associated or mixed with a diluent or vehicle, in a weight ratio of (I) to (II) at 0.5-5 (preferably 1-3). An independent claim is included for the production of (A), by combining (I) and (II) with one or more of diluents, filler, compression adjuvants, lubricants and/or disintegrating agents. ACTIVITY : Antifertility. Tests in 18-35 year old women having normal menstrual cycles involving administration of nomegestrol acetate (Ia) and estradiol (IIa) showed that (IIa) at 1.5 mg daily (i.e. a dose insufficient to block ovulation if used alone) potentiated the anti-ovulate effect of (Ia), so that an adequate ovulation inhibiting effect was obtained at low doses of (Ia) (i.we. 0.625 mg per day). MECHANISM OF ACTION : None given.
