Jennifer Treiberg;Amy Oliver;Ken Dick;Chanchal Sadhu;C. Gregory Sowell;Edward A. Kesicki
发明人:
Chanchal Sadhu,Ken Dick,Jennifer Treiberg,C. Gregory Sowell,Edward A. Kesicki,Amy Oliver
申请号：
US13399828
公开号：
US08637533B2
申请日:
2012.02.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3Kδ plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3Kδ, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity. Methods of using PI3Kδ inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3Kδ inhibitory compounds to inhibit PI3Kδ-mediated processes in vitro and in vivo.
