Transdermal or transmucosal pharmaceutical composition for treating nicotine dependency or for disaccustoming smokers, comprising nicotine, a nicotine derivatives or a nicotinergic substance in combination with at least one further active substance, characterized in that as additional active substance(s) it comprises at least one substance which acts on the central nervous system being selected from the group of the psychopharmaceuticals which embraces the active-substance group of the antidepressants, tranquilizers, nootropics, neuroleptics, or psychomimetics such as herein described wherein the nicotine and the active substance groups are present in a pharmaceutical effective amount..
