Sulan LUO,Dongting ZHANGSUN,Xiaopeng ZHU,Yong WU,Jinpeng YU,J. Michael MCINTOSH,David J. CRAIK
申请号：
US16470437
公开号：
US20190330275A1
申请日:
2017.12.20
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention belongs to the field of biochemistry and molecular biology. The present invention provides a mutant of α-conotoxin peptide TxID, a pharmaceutical composition and use thereof. The TxID mutant is capable of specifically blocking acetylcholine receptors (nAChRs), in particular, α3β4, or α6/α3β4 subtype, and has application prospects in the manufacture of a medicament for smoking cessation and detoxification and analgesia, a medicament for treating psychiatric diseases and cancers, regulating appetite, and a tool medicine for neuroscience.
