한양대학교 산학협력단;메사추세츠 인슈티튜트 오브 테크놀로지;INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人:
YUN, Chae Ok,윤채옥,LEE, Soo Hwan,이수환,KASALA, Dayananda,카살라다야난다,LANGER, Robert S.,랭거로버트 에스.
申请号：
KRKR2019/005516
公开号：
WO2019/235746A1
申请日:
2019.05.08
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to a technique for effective intranasal delivery to the brain. More particularly, the present invention provides an effect of applying to the diagnosis, prevention, or treatment of a central nervous system cerebral disease, or brain tumor by effectively delivering a drug to the brain through intranasal delivery with a pH-responsive, bioreducible PPA5 polymer, which can be used as a drug carrier.La présente invention concerne une technique d'administration intranasale efficace au cerveau. Plus particulièrement, la présente invention concerne un effet d'application au diagnostic, à la prévention, ou au traitement d'une maladie cérébrale du système nerveux central, ou d'une tumeur cérébrale en administrant efficacement un médicament au cerveau par l'administration intranasale d'un polymère PPA5 bioréductible, sensible au pH, qui peut être utilisé comme support de médicament.본 발명은 비강투여에 의한 효과적인 뇌전달 기술에 관한 것으로, 보다 상세하게는, 본 발명은 약물전달체로 사용할 수 있는 pH-감응형 생환원성 PPA5 폴리머를 비강투여하여 효과적으로 뇌로 전달함으로써 중추신경계 뇌질환, 신경퇴행성 질환, 또는 뇌종양의 진단, 예방 또는 치료에 사용하는 효과를 제공한다.
