What is provided is a rented agent for the treatment of flammability, autoimmunity and cancer. Claim 1: a compound (1) selected from the formula,Or its stereoisomer, Dow agent or salt acceptable for drug:R2 and R3 were selected independently from h, F, Cl, - nh832222；-NHCH₃,-N (CH)-Oh, oc832323,-8 832283；-OCH₂CH₂OH and C₁₋₃ alkyl；R830808 is from h, F, Cl, CN, - ch8322； - Oh, - CH (ch832323) Oh, - C (ch832323) 8322； - H (cf832323) Oh, - ch8322；； F, - chf832222；-CH₂CHF₂,-CF8323,-C (O) NH-C (O) NHCH-C (O) N (CH)-NH832222,-NHCH₃,-N (CH)-NHC (O) CH-Oh, oc832323,-8 832283；-Och 8322； - ch8322oh, cyclopapilor, cyclopapilmet, 1-hydrocyclopapler, imidazolilo, pirazolilo, 3-hydroxi-oxitan-3-ilo, oxetan-3-ilo and azetidin-1-ilo； r83099, selected from - ch832323；-CH₂CH₃,-CH₂OH, -CH₂F, -CHF₂,-CF8323,-Cn y-ch8322； - ch83222；； or two r83099 groups form a carbon cycle or heterocycle of 3, 4, 5 or 6 members； or one r83099 and r831222 group form a carbon cycle or heterocycle of 3, 4, 5 or 6 members； N group is 1, 2, 3 or 4； r8310 group is selected from h-ch832323；-CH₂CH₃,-Ch832228； - nh83222y-oh； r8311811 are selected from the structure of the preparation group (2),a. Corrugated line indicates connection point； r831222 is selected from - ch832323；-S (O) CHe. Cyclopentadiene, azetin-3-ilo, oxetan-3-ilo and morfolin-4-ilo； X1 is cr8313o n, selected from h, F, cl-ch-832313；-CH₂CH₃,-CH CH OH -NH-NHCH₃,-N (CH)-Oh, oc832323,-OCH₂CH₃ and -OCH₂CH₂OH； X² is CR¹⁰ or N, where R¹⁰ is selected from H, -CH₃,-Ch832228； - ch8323y-ch832228； - ch832228； - Oh； Y1 and Y2 are independently selected from CH and N, where y and N are not each n.Se proporcionan compuestos alquilados de piperazina, usados como medicamentos útiles en el tratamiento de enfermedades inflamatorias, autoinmunes y cáncer. Reivindicación 1: Un compuesto seleccionado de la fórmula (1), o sus estereoisómeros, tautómeros o sales farmacéuticamente aceptables, en donde: R¹, R² y R³ están seleccionados, de modo independiente, de H, F, Cl,
