This invention relates to a solid pharmaceutical composition that include a regulating agent of digestive and/or intestinal motility which has an agonist effect on peripheral μ, δ and κ opiate receptors； and an antiflatulent for the treatment and regulation of intestinal motility and flatulence in mammals. More in particularly, the pharmaceutical composition includes: (a) at least a regulating agent of intestinal motility such as trimebutine； (b) at least an antiflatulent such as simethicone； (c) at least a flowability promoter； (d) one or more lubricant； (e) at least an extender/diluent； (f) at least a disintegrant； and, (g) at least a binder.
