A fluorescence observation endoscope system includes a light source apparatus configured to be able to simultaneously emit light in a first wavelength band as fluorescence which is radiated onto medicine administered to a living body to thereby emit fluorescence, light in a second wavelength band and light in a third wavelength band which are visible light, an image pickup section configured to include an image pickup device to simultaneously receive the fluorescence and reflected light of the light in the second and third wavelength bands, and a signal processing apparatus configured to generate color display images from an image pickup signal of the fluorescence acquired by the image pickup section and second and third image pickup signals acquired from the reflected light of the light in the second and third wavelength bands to be displayed in different colors.
