A medical photothermal moxibustion instrument relates to a medical instrument. An instrument working power source and a general assembly plate of a moxibustion signal adjusting system are fixed in a shell a set key and a medical photothermal moxibustion head socket are installed on a panel of the shell and a plug is connected with a moxibustion head substrate via a signal connecting conductor. An S-shaped medicine line slot is arranged on the working face of the moxibustion head substrate, and the medicine line slot intersects with a wire connecting two light emitting diodes on the same diameter. Then the connected plug is inserted into a moxibustion head socket and a medicine line is squeezed into the medicine line slot. The difficulty that moxibustion medicine can not be placed in a V-shaped shallow pit of the moxibustion head and is easy to drop is effectively solved by changing the line burying way by means of squeezing the medicine line into the S-shaped or reversed S-shaped bent medicine line slot more tightly. Therefore, the simultaneous moxibustion of medicine, light and heat can be carried out conveniently, and the medical photothermal moxibustion instrument is beneficial for popularizing the modern moxibustion therapy technology and improving the therapeutic effect of the modern moxibustion therapy.