Ming-Jiu Chen,Chung-Ming Hsieh,Jije Gu,Susan Morgan-Lappe,Yingchun Li
申请号：
US15582112
公开号：
US20190315855A1
申请日:
2017.04.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
