A bone biopsy device (1) is disclosed, comprising an outer cannula (2) provided with a mouth (21) with a cutting edge (27) to section a frustule of spongy bone, a plate (4) mounted slidably within the cannula (2) and provided with a semi-cylindrical portion (41) at its distal end, and a stylet (7) mounted slidably within the plate (4) and provided with a pointed tip (70) which protrudes from the mouth of the cannula (2) to pierce the compact part of the bone. The mouth (21) of the cannula has on its inside a narrowing (23) and the semi-cylindrical part (41) of the plate has at its distal end at least one pair of opposed lunettes/anchorages (42, 43) adapted to bend, with respect to a horizontal plane, towards the interior of the semi-cylindrical portion (41) when they encounter the narrowing (23) of the mouth, so as to occlude the lumen (49) of the plate and clasp the base of the sectioned frustule and allow extraction of the frustule by means of the plate (4) whilst the cannula (2) is kept at the operating site, allowing aspiration of marrow after the frustule has been removed.
