An animal-machine audio interaction system includes a sound monitor for monitoring the sounds made by one or more animals, a sound segmenter for identifying coherent sound segments within the sounds made by the animal(s), a sound analyzer for analyzing and assigning a category to each sound segment, an output sound selector for selecting an output sound appropriate to the category assigned by the sound analyzer, and a sound output unit for outputting the selected output sound to the animal(s). A different control protocol may be used to define the categories assigned to the animal sounds and to determine the respective audio responses that are appropriate to the different sound categories. During operation of the system, a closed-loop audio interaction is set up between the animal(s) and the system. This interaction may be used for various purposes, such as investigating animal behavior, entertaining the animal(s) and controlling animal behavior.