A gelatin matrix pellet comprising a pre-defined amount of an active ingredient homogenously distributed therein in the absence of a water-miscible solvent that solubilizes and homogenizes the active ingredient. The active ingredient comprising at least one synthetic, semi-synthetic or natural cannabinoid, an extract of a cannabis plant, a combination of cannabis plant constituents, or a combination thereof, wherein the active ingredient comprises at least one of Tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinol (CBN), Cannabigerol (CBG), Cannabichromene (CBC), Cannabicyclol (CBL), Cannabivarin, (CBV), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV), Cannabichromevarin (CBCV), Cannabigerovarin (CBGV), Cannabigerol Monomethyl Ether (CBGM), an acid form, and a combination thereof.
