JULIET MARGUERITE GOODCHILD,COLIN STANLEY GOODCHILD,BENJAMIN JAMES BOYD
申请号：
GB201210657
公开号：
GB2491491A
申请日:
2011.01.19
申请国别(地区):
GB
年份:
2012
代理人:
摘要：
The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof, especially sulfobutyl ether β-cyclodextrin. The neuroactive steroid may be alphaxolone, alphadolone, allopregnanolone or eltanolone (pregnanolone). The formulation may additionally comprise an antimicrobial agent, a preservative, a buffer and/or a copolymer, particularly hydroxypropyl methylcellulose (HPMC), polyvinyl pyrrolidone (PVP) or carboxymethylcellulose. The composition may be administered by infusion or bolus.
