598247 Disclosed herein are compositions of receptor inhibitors, including typical antipsychotic agents, for example haloperidol, and methods of use for treating clinical signs or symptoms of Parkinson&rsquos disease. Furthermore, this application describes compositions and methods to induce supersensitivity in dopamine D2 and other receptors involved in Parkinson&rsquos disease as a means of alleviating the clinical signs or symptoms of Parkinson&rsquos disease.