The invention relates to systems and methods for monitoring the long term health of the peritoneum and catheter in a patient undergoing peritoneal dialysis (PD) treatment. The systems and methods include processors and sensors for determining changes in the peritoneum health or catheter of a PD patient to support analysis, replacement, and possible medical intervention. The method can include receiving a prior history of a patient storing the prior history in a machine-readable storage medium, which when executed performs the steps of trending the one or more fluid parameters from the prior history and determining a change in peritoneum health or catheter patency from the trended prior history. The system can include a peritoneal dialysis cycler having an infusion line and an effluent line at least one sensor positioned in the infusion line, the effluent line, or combinations thereof and a processor in communication with the sensor.
