Jitin Bajaj,Michael Albert Winters,Emily Wen,Jian He
申请号：
US16482349
公开号：
US20200046821A1
申请日:
2018.01.30
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides methods for making polysaccharide-protein conjugates in which polysaccharides, typically from bacteria, are conjugated to a carrier protein by reductive amination under conditions which improve conjugation reaction consistency, increase consumption of protein during conjugation reaction, generate conjugates of higher molecular weight, and/or reduce the levels of free cyanide in the conjugate reaction product. The polysaccharide-protein conjugates obtained using these methods are useful for inclusion in multivalent vaccines.
