#$%^&*AU2016222315A120170330.pdf#####ABSTRACT OF THE DISCLOSURE The present application relates to compositions comprising selenium compounds, such as 5'-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of Formula (I), Formula (II), 5 or Formula (III), and combinations thereof, and methods of using the same for modulating glucose metabolism in a subject.