Patrick BAEUERLE,Jeanmarie GUENOT,Holger WESCHE,Robert B. DUBRIDGE,Bryan D. LEMON,Richard J. AUSTIN,Pui SETO
申请号：
US15821530
公开号：
US20180162949A1
申请日:
2017.11.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are prostate specific membrane antigen (PSMA) targeting trispecific proteins comprising a domain binding to CD3, a half-life extension domain, and a domain binding to PSMA. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such PSMA targeting trispecific proteins. Also disclosed are methods of using the disclosed PSMA targeting trispecific proteins in the prevention, and/or treatment diseases, conditions and disorders.
