FACTEUR DE CROISSANCE DES TISSUS CONJONCTIFS

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专利权人:

UNIVERSITY OF SOUTH FLORIDA

发明人:

GROTENDORST, GARY R.,BRADHAM, DOUGLASS M.

申请号：

CA2222509

公开号：

CA2222509C

申请日:

1996.05.31

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

The present invention provides a novel polypeptide, Connective Tissue GrowthFactor (CTGF), polynucleotides CTGF, and including 5'and 3' untranslatednucleotides, antibodies reactive with CTGF and means for producing CTGF. Alsoprovided are diagnostic and therapeutic methods for using CTGF, as well as anassay for identifying compositions which affect the expression of CTGFpolynucleotide. The invention provides a novel TGF-.beta. responsive elementupstream of the polynucleotide encoding CTGF structural gene.

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