Device for the treatment of tissue calcification, in particular aortic valve leaflets, characterized by the fact that it comprises a first ultrasound emission unit that is adapted to provide ultrasound waves with MHz frequencies and a second ultrasound emission unit that is adapted to provide ultrasound waves with KHz frequencies.The invention also includes a method for the treatment of tissue calcification that is characterized by the simultaneous use of ultrasound waves with MHz frequencies and ultrasound waves with KHz frequencies.