As for this invention, especially, being the human immunoglobulin which is connected to the human EpCAM antigen uniquely, being the method of dealing with the tumor characteristic disease in the human patient by prescribing the immunoglobulin which at least shows the serum middle half-life of 15 days to the patient, the aforementioned immunoglobulin at the frequency which every week does not exceed 1 times, it regards the method of including the stage which is prescribed at the frequency which does not exceed 1 times desirably 2 weeks.本発明は、特に、ヒトEpCAM抗原に特異的に結合するヒト免疫グロブリンであって少なくとも15日の血清中半減期を示す免疫グロブリンを患者に投与することにより、ヒト患者における腫瘍性疾患を処置する方法であって、前記免疫グロブリンを毎週1回を上回らない頻度で、好ましくは2週毎に1回を上回らない頻度で投与する段階を含む方法に関する。
