The present invention relates to the field of vaccines directed against viruses of the HIV family. More particularly, it relates to an immunogenic compound comprising a peptide of the following formula (I) NH 2 -[Nt] y -P-W-N-X -S-X 2 -S-N-X 3 -X 4 -X -X 6 -X 7 -I-W-[Ct] z -COOH (I) which is covalently linked to a carrier protein consisting of a CRM197 protein. It also concerns a composition containing this immunogenic compoundand the uses of theseimmunogenic compounds andcompositionsfor preventing and/or treating a condition caused by the infection of an individual with a HIV virus.